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rap1 GTPase-GDP dissociation stimulator 1; SMG GDS protein; SMG P21 stimulatory GDP/GTP exchange protein; exchange factor smgGDS (RAP1GDS1)
Function:
- guanine nucleotide exchange factor
- stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including rap1a/rap1b, RhoA, RhoB & KRas, by stimulating dissociation of GDP from & the subsequent binding of GTP to each small G protein
Structure: contains 5 ARM repeats
Alternative splicing: named isoforms=2
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: entity length = 607 aa
MW = 66 kD
MOTIF: ARM repeat {77-118}
ARM repeat {169-211}
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
ARM repeat {346-390}
ARM repeat {391-431}
ARM repeat {479-519}
Database Correlations
OMIM 179502
UniProt P52306
Pfam PF00514
Entrez Gene 5910
References
- UniProt :accession P52306
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/RAP1GDS1ID400.html
- Boguski MS & McCormick F
Proteins regulating Ras and its relative.
Nature 366:643 1993
PMID: 8259209