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SMG1C complex
Function:
- role in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons
- recruited by release factors to stalled ribosomes
- recruitment of SMG8 to SMG1 N-terminus induces a large conformational change in the SMG1 C-terminal head domain containing the catalytic domain
- SMG8 heterodimers with SMG9 may represent a SMG1C intermediate form
Structure:
- subunits include: SMG1, SMG8 & SMG9
General
molecular complex
Properties
SUBUNITS: serine/threonine protein kinase SMG1
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: SMG8/SMG9 interaction {1-1977}
MOTIF: FAT domain
NAME: FAT domain
SITE: 1131-1866
MOTIF: Tyr phosphorylation site
binding site
FOR-BINDING-OF: Paxillin
HEAT repeat {1817-1852}
PI3K/PI4K {2150-2478}
Thr phosphorylation site {T3550}
Ser phosphorylation site {S3556}
Ser phosphorylation site {S3570}
Thr phosphorylation site {T3573}
Ser phosphorylation site {S3576}
Thr phosphorylation site {T3577}
FATC {3629-3661}
STATE: active state
protein SMG8
MOTIF: Ser phosphorylation site {S469}
protein SMG9
MOTIF: Ser phosphorylation site {S4}
Ser phosphorylation site {S7}
Ser phosphorylation site {S32}
Ser phosphorylation site {S53}
proline-rich region
SITE: 71-133
MOTIF: proline residue (SEVERAL)
Tyr phosphorylation site {Y147}
Ser phosphorylation site {S451}
References
UniProt :accession Q8ND04
Components
protein SMG8; amplified in breast cancer gene 2 protein; protein smg-8 homolog (SMG8 ABC2 C17orf71)
protein SMG9; protein smg-9 homolog (SMG9, C19orf61)
serine/threonine protein kinase SMG1; SMG-1; hSMG-1; 61E3.4; lambda/iota protein kinase C-interacting protein; lambda-interacting protein (SMG1, ATX, KIAA0421, LIP)