SMC5-SMC6 complex

Function: - role in repair of DNA double-strand breaks by homologous recombination - may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks Structure: - subunits: SMC5, SMC6, NSMCE2/MMS21 & probably NSMCE1

Properties

SUBUNITS: structural maintenance of chromosomes protein 5 COMPARTMENT: cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 80-87 coiled coil {207-445} coiled coil {647-828} coiled coil {888-927} structural maintenance of chromosomes protein 6 COMPARTMENT: cell nucleus MOTIF: ATP-binding site NAME: ATP-binding site SITE: 76-83 coiled coil {226-451} coiled coil {660-914} E3 SUMO-protein ligase NSE2 COMPARTMENT: cell nucleus MOTIF: RING-finger {154-236} EFFECTOR-BOUND: Zn+2 FOR-BINDING-OF: DNA motif non-structural maintenance of chromosomes element 1 homolog COMPARTMENT: cell nucleus MOTIF: Zinc finger NAME: Zinc finger SITE: 188-234 EFFECTOR-BOUND: Zn+2

References

UniProt :accession Q9NZI8, Q9BZF9

Components

E3 SUMO-protein ligase NSE2 (non-structural maintenance of chromosomes element 2 homolog, non-SMC element 2 homolog, hMMS21, NSMCE2, C8orf36, MMS21) non-structural maintenance of chromosomes element 1 homolog (non-SMC element 1 homolog, NSMCE1) structural maintenance of chromosomes protein 5 (hSMC5, SMC5, KIAA0594, SMC5L1) structural maintenance of chromosomes protein 6 (hSMC6, SMC6, SMC6L1)