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small ubiquitin-related modifier 5; SUMO-5; SUMO1 pseudogene 1; ubiquitin-like 2; ubiquitin-like 6 (SUMO1P1, SUMO5 ,,,, UBL2, UBL6)
Function:
- ubiquitin-like protein
- can be covalently attached to proteins as a monomer or as a lysine-linked polymer
- regulates the life cycle of promyelocytic leukemia nuclear bodies (PML-NBs)
- polySUMO1P1/SUMO5 conjugation on 'Lys-160' of PML facilitates recruitment of PML-NB components, which enlarges PML-NB
- SUMO1P1/SUMO5 also increases polySUMO2/3 conjugation of PML, resulting in RNF4- mediated disruption of PML-NBs
- cleavage of precursor form is necessary for function
- autosumoylated at Lys-18
- interacts with CBX4
- interacts with PIAS1
- found in a complex with SAE2
- interacts with UBE2I
- interacts with SP100
- interacts with HIPK2
- interactswith DAXX
- interacts with PML-RARA oncoprotein;
- PML-RARalpha outcompetes PML for SUMO1P1/SUMO5 conjugation
Structure: belongs to the ubiquitin family, SUMO subfamily
Compartment:
- nucleus
- forms prominent non-membrane-bound structures in the nucleus
Expression:
- high expression levels in testes & peripheral blood leukocytes
- also expressed in lung, placenta, liver, spleen & thymus Comparative biolgy:
- highly conserved among primate species,
- not detected in mice
Note:
- defined as a pseudogene by HGNC; hwever the existence of the functional protein is supported by the inhibition of its expression & its function using siRNAs specifically targeting SUMO1P1/SUMO5
General
nuclear protein
Properties
SIZE: entity length = 101 aa
MW = 12 kD
COMPARTMENT: cell nucleus
MOTIF: peptide motif
Database Correlations
UniProt G2XKQ0
Pfam PF11976
References
- UniProt :accession G2XKQ0
- PMID: 27211601