small transmembrane & glycosylated protein (SMAGP)

Function: - may play a role in epithelial cell-cell contacts Structure: - O-glycosylated - O-glycan is modified with sialic acid residues - belongs to the SMAGP family Compartment: - cell membrane - cytoplasmic vesicle - predominantly on lateral parts of the membrane, at cell-cell epithelial junctions Expression: - detected in breast, endometrium, colon & biliary tract - detected in polarized epithelial structures characterized by cell-cell adhesion (at protein level) Pathology: - may play a role in tumor invasiveness & metastasis formation - detected on cytoplasmic membranes in undifferentiated tumors

General

glycoprotein membrane protein

Properties

SIZE: entity length = 97 aa MW = 11 kD COMPARTMENT: cytoplasm MOTIF: Thr glycosylation site {T2} Ser glycosylation site {S3} Thr glycosylation site {T6} Thr glycosylation site {T7} Ser glycosylation site {S9} Thr glycosylation site {T16} Thr glycosylation site {T17} Thr glycosylation site {T23} transmembrane domain {37-57}

Database Correlations

UniProt Q0VAQ4 Kegg hsa:5722

References

UniProt :accession Q0VAQ4