small proline-rich protein 2F (SPR-2F, SPRR2F)

Function: - cross-linked envelope protein of keratinocytes - keratinocyte protein that first appears in the cell cytosol - ultimately becomes cross-linked to membrane proteins by transglutaminase - process results in the formation of an insoluble envelope beneath the plasma membrane (putative) Structure: belongs to the cornifin (SPRR) family Compartment: cytoplasm (putative) Expression: - induced during squamous differentiation of epidermal keratinocytes (putative)

Properties

SIZE: MW = 8 kD entity length = 72 aa COMPARTMENT: cytoplasm MOTIF: proline-rich region SITE: 21-47 MOTIF: proline residue (SEVERAL) consensus repeat {21-29} SEQUENCE-IS: [PS]-K-C-P-[EQ]-[PS]-C-P-P consensus repeat {30-38} SEQUENCE-IS: [PS]-K-C-P-[EQ]-[PS]-C-P-P consensus repeat {39-47} SEQUENCE-IS: [PS]-K-C-P-[EQ]-[PS]-C-P-P

References

UniProt :accession Q96RM1