small breast epithelial mucin; protein (BS106, SBEM, MUCL1)

Function: - O-glycosylated (probable) Compartment: secreted (probable), membrane (Probable) Expression: - expressed in mammary gland, salivary glands & prostate - detected in lung Polymorphism: The number of repeats varies from 3 to 2 in one variant form which is equally present in breast cancer tumors Pathology: - may play a role as marker for diagnosis of metastatic breast cancer - mainly expressed in cancer cell lines of breast origin - highly expressed in lymph node-positive compared with node-negative breast cancer - detected in all lymph node containing metastatic breast cancer cells

General

membrane protein secreted protein

Properties

SIZE: MW = 9 kD entity length = 90 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-20} threonine-rich region {23-68} MOTIF: threonine residue (SEVERAL) Thr glycosylation site {T23} Thr glycosylation site {T24} Thr glycosylation site {T30} Thr glycosylation site {T34} repeats {46-69} MOTIF: consensus repeat {46-53} SEQUENCE-IS: T-T-A-A-[APS]-T-T-A Thr glycosylation site {T46} Thr glycosylation site {T47} Thr glycosylation site {T51} Thr glycosylation site {T52} consensus repeat {54-61} SEQUENCE-IS: T-T-A-A-[APS]-T-T-A Thr glycosylation site {T54} Thr glycosylation site {T55} Thr glycosylation site {T59} Thr glycosylation site {T60} consensus repeat {62-69} SEQUENCE-IS: T-T-A-A-[APS]-T-T-A Thr glycosylation site {T62} Thr glycosylation site {T63} Ser glycosylation site {S66} Thr glycosylation site {T67} Thr glycosylation site {T68}

References

UniProt :accession Q96DR8