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smad nuclear-interacting protein 1; FHA domain-containing protein SNIP1 (SNIP1)
Function:
- inhibits SMAD2/SMAD3 binding to DNA
- down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding
- involved in the microRNA (miRNA) biogenesis
- degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex
- phosphorylated upon DNA damage, probably by ATM or ATR
- binds SMAD4 & CREBBP/EP300
- binds the ADH1/OAZ1/PSMB4 complex
- interacts with RNASEN
Structure:
- contains 1 FHA domain
Compartment:
- nucleus
Expression:
- ubiquitous
- highest expression in cardiac muscle & skeletal muscle
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 396 aa
MW = 46 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S35}
Ser phosphorylation site {S49}
Ser phosphorylation site {S52}
Ser phosphorylation site {S54}
arginine-rich region {62-192}
MOTIF: arginine residue (SEVERAL)
Ser phosphorylation site {S89}
Ser phosphorylation site {S91}
Ser phosphorylation site {S153}
coiled coil {165-196}
MOTIF: Thr phosphorylation site {T169}
Ser phosphorylation site {S202}
forkhead-associated (FHA) domain {281-344}
glutamate-rich region {385-392}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S394}
Database Correlations
OMIM 608241
UniProt Q8TAD8
Pfam PF00498
Entrez Gene 79753
Kegg hsa:79753
References
UniProt :accession Q8TAD8