SMAD6/MADH6; mothers against decapentaplegic homolog 6; mothers against DPP homolog 6; MAD homolog 6; SMAD family member 6; SMAD 6; smad6; hSMAD6 (SMAD6, MADH6)

Function: - antagonist of signaling by TGF-beta type 1 receptor superfamily members - inhibits selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1 - inhibits phosphorylation of SMAD2 but perhaps not SMAD3 - SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD - binds to regulatory elements in target promoter regions - phosphorylated by BMP type 1 receptor kinase & by PRKX - interacts with NEDD4L (putative) - interacts with RNF111 & AXIN1 - interacts with TGF-beta type 1 receptor superfamily members, SMAD1, HOXC8 & HOXC9 - interacts with STAMBP & PRKX Structure: - belongs to the dwarfin/SMAD family - contains 1 MH1 (MAD homology 1) domain - contains 1 MH2 (MAD homology 2) domain Compartment: - nucleus Alternative splicing: - named isoforms=3; A, B, D Expression: - ubiquitous in various organs, with higher levels in lung - isoform B is up-regulated in diseased heart tissue

General

nuclear protein phosphoprotein SMAD protein

Properties

SIZE: entity length = 496 aa MW = 53 kD COMPARTMENT: cell nucleus MOTIF: glycine-rich region {25-33} arginine-rich region {82-85} MOTIF: arginine residue (SEVERAL) MH1 domain {148-275} MOTIF: alanine-rich region {251-254} MOTIF: alanine residue (SEVERAL) proline-rich region SITE: 275-278 MOTIF: proline residue (SEVERAL) MH2 domain {331-496} MOTIF: Ser phosphorylation site {S435}

References

UniProt :accession O43541

Databases & Figures

OMIM 602931 UniProt O43541 PFAM correlations Entrez Gene 4091 Kegg hsa:4091 TGF-beta/BMP signaling