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SMAD3/SMAD4
Function:
- phosphorylated SMAD3 binds to SMAD4 & enters the nucleus SMAD2/SMAD4 & SMAD3/SMAD4 complexes interact with transcription factors:
- activating transcription factor 2 (ATF2)
- CREB-binding protein
- p300 transcriptional adaptor protein
- sno-N antagonizes TGF-beta signalling through direct interactions with SMAD2/SMAD4 & SMAD3/SMAD4.
General
molecular complex
nuclear protein
Properties
COMPARTMENT: cell nucleus
SUBUNITS: SMAD3 protein
MOTIF: Thr phosphorylation site {T8}
MH1 domain {10-136}
MH2 domain {232-425}
MOTIF: domain {271-324}
Ser phosphorylation site {S416}
Ser phosphorylation site {S423}
Ser phosphorylation site {S425}
SMAD4 protein
MOTIF: MH1 domain {N-TERMINUS}
MH1 domain {18-142}
proline-rich region
MOTIF: proline residue (SEVERAL)
SAD {275-320}
MH2 domain {323-552}
MOTIF: alanine-rich region {451-466}
MOTIF: alanine residue (SEVERAL)
MH2 domain {C-TERMINUS}
Components
SMAD3/MADH3; mothers against decapentaplegic homolog 3; mothers against DPP homolog 3; MAD homolog 3; Mad3; hMAD-3; SMAD family member 3; SMAD 3; smad3; hSMAD3; JV15-2 (SMAD3, MADH3)
SMAD4/MADH4; mothers against decapentaplegic homolog 4; mothers against DPP homolog 4; MAD homolog 4; SMAD family member 4; SMAD 4; smad4; hSMAD4; deletion target in pancreatic carcinoma 4 (SMAD4, DPC4, MADH4)