SMAD2/SMAD4

Function: - phosphorylated SMAD2 binds to SMAD4 & enters the nucleus - SMAD2/SMAD4 & SMAD3/SMAD4 complexes interact with transcription factors: - activating transcription factor 2 (ATF2) - CREB-binding protein - p300 transcriptional adaptor protein - SMAD2/SMA4 interacts with forkhead activin signal transducer 2 - sno-N antagonizes TGF-beta signalling through direct interactions with SMAD2/SMAD4 & SMAD3/SMAD4.

General

molecular complex nuclear protein

Properties

COMPARTMENT: cell nucleus SUBUNITS: SMAD2 protein MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Thr phosphorylation site {T8} MH1 domain {10-176} Thr phosphorylation site {T220} PY {221-225} Ser phosphorylation site {S240} Ser phosphorylation site {S245} Ser phosphorylation site {S250} Ser phosphorylation site {S255} MH2 domain {274-467} MOTIF: Ser phosphorylation site {S458} Ser phosphorylation site {S465} Ser phosphorylation site {S467} SMAD4 protein MOTIF: MH1 domain {N-TERMINUS} MH1 domain {18-142} proline-rich region MOTIF: proline residue (SEVERAL) SAD {275-320} MH2 domain {323-552} MOTIF: alanine-rich region {451-466} MOTIF: alanine residue (SEVERAL) MH2 domain {C-TERMINUS}

Components

SMAD2/MADH2; mothers against decapentaplegic homolog 2; mothers against DPP homolog 2; MAD homolog 2; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; smad2; hSMAD2; JV18-1 (SMAD2, MADH2, MADR2) SMAD4/MADH4; mothers against decapentaplegic homolog 4; mothers against DPP homolog 4; MAD homolog 4; SMAD family member 4; SMAD 4; smad4; hSMAD4; deletion target in pancreatic carcinoma 4 (SMAD4, DPC4, MADH4)