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Slit homolog 3 protein; Slit-3; multiple EGF-like domains protein 5 (SLIT3, KIAA0814, MEGF5, SLIL2, UNQ691/PRO1336)
Function:
- may act as molecular guidance cue in cellular migration
- function may be mediated by interaction with roundabout homolog receptors
Structure:
- contains 1 CTCK (C-terminal cystine knot-like) domain
- contains 9 EGF-like domains
- contains 1 laminin G-like domain
- contains 20 LRR repeats (leucine-rich repeats)
- contains 4 LRRCT domains
- contains 4 LRRNT domains
Compartment: secreted (putative)
Alternative splicing: named isoforms=3
Expression: predominantly expressed in thyroid
General
leucine-rich repeat-containing protein (LRRC)
multiple epidermal growth factor like domains (protein)
slit homolog protein
Properties
SIZE: entity length = 1523 aa
MW = 168 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-33}
LRRNT {34-61}
leucine-rich repeat
SITE: 62-83
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N72}
leucine-rich repeat
SITE: 86-107
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 110-131
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 134-155
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 158-179
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 182-203
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N192}
LRRCT 1 {215-265}
LRRNT 2 {271-307}
MOTIF: cysteine residue {C284}
MODIFICATION: cysteine residue {C293}
cysteine residue {C293}
MODIFICATION: cysteine residue {C284}
leucine-rich repeat
SITE: 308-329
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 332-353
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 356-377
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 380-401
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 404-425
MOTIF: leucine residue (SEVERAL)
LRRCT 2 {437-487}
MOTIF: cysteine residue {C441}
MODIFICATION: cysteine residue {C464}
cysteine residue {C443}
MODIFICATION: cysteine residue {C485}
cysteine residue {C464}
MODIFICATION: cysteine residue {C441}
cysteine residue {C485}
MODIFICATION: cysteine residue {C443}
LRRNT 3 {496-532}
MOTIF: cysteine residue {C505}
MODIFICATION: cysteine residue {C511}
cysteine residue {C509}
MODIFICATION: cysteine residue {C518}
cysteine residue {C511}
MODIFICATION: cysteine residue {C505}
cysteine residue {C518}
MODIFICATION: cysteine residue {C509}
leucine-rich repeat
SITE: 533-554
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 558-579
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N563}
leucine-rich repeat
SITE: 582-603
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 606-627
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N622}
leucine-rich repeat
SITE: 630-651
MOTIF: leucine residue (SEVERAL)
LRRCT 3 {663-713}
MOTIF: cysteine residue {C667}
MODIFICATION: cysteine residue {C690}
cysteine residue {C669}
MODIFICATION: cysteine residue {C711}
cysteine residue {C690}
MODIFICATION: cysteine residue {C667}
cysteine residue {C711}
MODIFICATION: cysteine residue {C669}
LRRNT 4 {716-752}
leucine-rich repeat
SITE: 753-775
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 776-797
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N784}
N-glycosylation site {N792}
N-glycosylation site {N797}
leucine-rich repeat
SITE: 800-821
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 824-845
MOTIF: leucine residue (SEVERAL)
LRRCT 4 {857-907}
EGF domain {918-953}
MOTIF: cysteine residue {C920}
MODIFICATION: cysteine residue {C931}
cysteine residue {C925}
MODIFICATION: cysteine residue {C941}
N-glycosylation site {N928}
cysteine residue {C931}
MODIFICATION: cysteine residue {C920}
cysteine residue {C941}
MODIFICATION: cysteine residue {C925}
cysteine residue {C943}
MODIFICATION: cysteine residue {C952}
cysteine residue {C952}
MODIFICATION: cysteine residue {C943}
EGF domain {955-994}
MOTIF: cysteine residue {C959}
MODIFICATION: cysteine residue {C970}
cysteine residue {C964}
MODIFICATION: cysteine residue {C982}
cysteine residue {C970}
MODIFICATION: cysteine residue {C959}
cysteine residue {C982}
MODIFICATION: cysteine residue {C964}
cysteine residue {C984}
MODIFICATION: cysteine residue {C993}
cysteine residue {C993}
MODIFICATION: cysteine residue {C984}
EGF domain {996-1032}
MOTIF: cysteine residue {C1000}
MODIFICATION: cysteine residue {C1011}
cysteine residue {C1005}
MODIFICATION: cysteine residue {C1020}
N-glycosylation site {N1008}
cysteine residue {C1011}
MODIFICATION: cysteine residue {C1000}
cysteine residue {C1020}
MODIFICATION: cysteine residue {C1005}
cysteine residue {C1022}
MODIFICATION: cysteine residue {C1031}
N-glycosylation site {N1025}
cysteine residue {C1031}
MODIFICATION: cysteine residue {C1022}
EGF domain {1034-1072}
MOTIF: cysteine residue {C1038}
MODIFICATION: cysteine residue {C1051}
cysteine residue {C1045}
MODIFICATION: cysteine residue {C1060}
cysteine residue {C1051}
MODIFICATION: cysteine residue {C1038}
cysteine residue {C1060}
MODIFICATION: cysteine residue {C1045}
cysteine residue {C1062}
MODIFICATION: cysteine residue {C1071}
cysteine residue {C1071}
MODIFICATION: cysteine residue {C1062}
EGF domain {1074-1110}
MOTIF: cysteine residue {C1078}
MODIFICATION: cysteine residue {C1089}
cysteine residue {C1083}
MODIFICATION: cysteine residue {C1098}
cysteine residue {C1089}
MODIFICATION: cysteine residue {C1078}
cysteine residue {C1098}
MODIFICATION: cysteine residue {C1083}
cysteine residue {C1100}
MODIFICATION: cysteine residue {C1109}
cysteine residue {C1109}
MODIFICATION: cysteine residue {C1100}
EGF domain {1119-1155}
MOTIF: cysteine residue {C1123}
MODIFICATION: cysteine residue {C1134}
cysteine residue {C1128}
MODIFICATION: cysteine residue {C1143}
cysteine residue {C1134}
MODIFICATION: cysteine residue {C1123}
cysteine residue {C1143}
MODIFICATION: cysteine residue {C1128}
cysteine residue {C1145}
MODIFICATION: cysteine residue {C1154}
cysteine residue {C1154}
MODIFICATION: cysteine residue {C1145}
Laminin G-like {1158-1332}
MOTIF: N-glycosylation site {N1181}
N-glycosylation site {N1247}
cysteine residue {C1305}
MODIFICATION: cysteine residue {C1332}
cysteine residue {C1332}
MODIFICATION: cysteine residue {C1305}
EGF domain {1340-1365}
MOTIF: cysteine residue {C1355}
MODIFICATION: cysteine residue {C1364}
cysteine residue {C1364}
MODIFICATION: cysteine residue {C1355}
EGF domain {1368-1403}
MOTIF: cysteine residue {C1372}
MODIFICATION: cysteine residue {C1382}
cysteine residue {C1377}
MODIFICATION: cysteine residue {C1391}
cysteine residue {C1382}
MODIFICATION: cysteine residue {C1372}
cysteine residue {C1391}
MODIFICATION: cysteine residue {C1377}
cysteine residue {C1393}
MODIFICATION: cysteine residue {C1402}
cysteine residue {C1402}
MODIFICATION: cysteine residue {C1393}
N-glycosylation site {N1406}
EGF domain {1408-1444}
MOTIF: cysteine residue {C1412}
MODIFICATION: cysteine residue {C1422}
cysteine residue {C1417}
MODIFICATION: cysteine residue {C1432}
cysteine residue {C1422}
MODIFICATION: cysteine residue {C1412}
cysteine residue {C1432}
MODIFICATION: cysteine residue {C1417}
cysteine residue {C1434}
MODIFICATION: cysteine residue {C1443}
cysteine residue {C1443}
MODIFICATION: cysteine residue {C1434}
C-terminal cystine knot {1449-1523}
MOTIF: cysteine residue {C1449}
MODIFICATION: cysteine residue {C1487}
cysteine residue {C1467}
MODIFICATION: cysteine residue {C1501}
cysteine residue {C1478}
MODIFICATION: cysteine residue {C1517}
cysteine residue {C1482}
MODIFICATION: cysteine residue {C1519}
cysteine residue {C1487}
MODIFICATION: cysteine residue {C1449}
cysteine residue {C1501}
MODIFICATION: cysteine residue {C1467}
cysteine residue {C1517}
MODIFICATION: cysteine residue {C1478}
cysteine residue {C1519}
MODIFICATION: cysteine residue {C1482}
Database Correlations
OMIM 603745
UniProt O75094
PFAM correlations
Entrez Gene 6586
Kegg hsa:6586
References
UniProt :accession O75094