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SLIT & NTRK-like protein 4 (SLITRK4)

Function: - suppresses neurite outgrowth Structure: - belongs to the SLITRK family - contains 18 LRR repeats (leucine-rich repeats) Compartment: membrane Expression: - expressed in the cerebral cortex & at higher levels in some astrocytic brain tumors including astrocytomas, glioblastomas & primitive neuroectodermal tumors

General

glycoprotein membrane protein SLIT & NTRK-like protein (SLITRK)

Properties

SIZE: MW = 94 kD entity length = 837 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-18} leucine-rich repeat SITE: 58-81 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N81} leucine-rich repeat SITE: 82-105 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 106-129 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 131-153 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 154-177 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 179-201 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 203-215 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 216-238 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 312-336 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N325} leucine-rich repeat SITE: 376-399 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 400-423 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 424-447 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 449-471 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 472-495 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 497-519 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 521-547 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 555-581 MOTIF: leucine residue (SEVERAL) transmembrane domain {619-639} leucine-rich repeat SITE: 665-688 MOTIF: leucine residue (SEVERAL)

Database Correlations

UniProt Q8IW52 PFAM correlations

References

UniProt :accession Q8IW52