SLIT & NTRK-like protein 2 (SLITRK2, CXorf2, KIAA1854, SLITL1, UNQ9197/PRO34756)

Function: - suppresses neurite outgrowth Structure: - belongs to the SLITRK family - contains 14 LRR repeats (leucine-rich repeats) Compartment: membrane Alternative splicing: named isoforms=2 Expression: - expressed predominantly in cerebral cortex, but also at low levels in spinal cord & medulla - expressed in some astrocytic brain tumors, including astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas & primitive neuroectodermal tumors

General

glycoprotein membrane protein SLIT & NTRK-like protein (SLITRK)

Properties

SIZE: MW = 95 kD entity length = 845 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-21} leucine-rich repeat SITE: 61-84 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N84} leucine-rich repeat SITE: 85-108 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 109-132 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 134-156 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 157-180 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 182-204 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 241-264 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 374-397 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 398-421 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N421} leucine-rich repeat SITE: 422-445 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 447-469 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 470-493 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 495-517 MOTIF: leucine residue (SEVERAL) transmembrane domain {622-642} leucine-rich repeat SITE: 763-786 MOTIF: leucine residue (SEVERAL)

Database Correlations

UniProt Q9H156 PFAM correlations

References

UniProt :accession Q9H156