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sleep fragmentation

Physiology: - sleep fragmentation may share a causal link with lucid dreaming Pathology: - sleep fragmentation disrupts sleep architecture, increases fatigue & diminishes inhibition [5] - elderly may be less able to compenstate for effects of sleep fragmentation o fatigue [5] - sleep fragmentation is associated with worse cognitive impairment at 7 days post ICU discharge after critical illness Comparative biology: - in mice, sleep fragmentation affects cognitive behaviors associated with learning & memory correlated with a decrease in aquaporin-4 (AQP4) which plays a role in the glymphatic system [4] - in mice, sleep fragmentation increases hippocampal microgliosis & decreases CA1 neuronal activity [3] - in the hypothalamus sleep fragmentation suppresses neuronal activity in the paraventricular nucleus [3] - traumatic brain injury & sleep fragmention induce deficits in Schaffer collateral long-term potentiation associated with impaired acquisition of fear conditioning, a result of dorsal hippocampal-dependent cognitive deficits

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sleep disorder

References

  1. Gott J, Rak M, Bovy L et al Sleep fragmentation and lucid dreaming. Conscious Cogn. 2020 Sep;84:102988. PMID: 32768920 Free article.
  2. Wilcox ME, McAndrews MP, Van J et al Sleep Fragmentation and Cognitive Trajectories After Critical Illness. Chest. 2021 Jan;159(1):366-381. PMID: 32717265
  3. Tapp ZM, Cornelius S, Oberster A Sleep fragmentation engages stress-responsive circuitry, enhances inflammation and compromises hippocampal function following traumatic brain injury. Exp Neurol. 2022 Jul;353:114058. PMID: 35358498 Free PMC article.
  4. Vasciaveo V, Iadarola A, Casile A et al Sleep fragmentation affects glymphatic system through the different expression of AQP4 in wild type and 5xFAD mouse models. Acta Neuropathol Commun. 2023 Jan 18;11(1):16. PMID: 36653878 Free PMC article.
  5. Benkirane O, Delwiche B, Mairesse O, Peigneux P. Impact of Sleep Fragmentation on Cognition and Fatigue. Int J Environ Res Public Health. 2022 Nov 22;19(23):15485. PMID: 36497559 Free PMC article.