SLC2A4 regulator (GLUT4 enhancer factor, GEF, Huntington disease gene regulatory region-binding protein 1, HDBP-1, SLC2A4RG, HDBP1)

Function: - transcription factor involved in SLC2A4 & HD gene transactivation. - binds to the consensus sequence 5'-GCCGGCG-3' - interacts with MEF2A Structure: - contains 1 C2H2-type zinc finger Compartment: - cytoplasm, nucleus - shuttles between cytoplasm & nucleus Alternative splicing: named isoforms=2 Expression: 1) expressed in heart, skeletal muscle, liver, kidney, pancreas undetectable in lung, placenta or brain 2) ubiquitously expressed, with lowest expression in brain & ileum * two accounts of expression (see UniProt)

General

C2H2 type zinc finger protein DNA-binding protein transcription factor (TF)

Properties

SIZE: MW = 41 kD entity length = 387 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: serine-rich region {147-154} MOTIF: serine residue (SEVERAL) Zn finger C2H2-type SITE: 200-225 EFFECTOR-BOUND: Zn+2 nuclear export signal {253-263} proline-rich region SITE: 293-302 MOTIF: proline residue (SEVERAL) nuclear translocation signal {351-354}

Database Correlations

UniProt Q9NR83 Pfam PF00096

References

UniProt :accession Q9NR83