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Sjoegren syndrome/scleroderma autoantigen 1; autoantigen p27 (SSSCA1)
Function:
- might play a role in mitosis
- could be a centromere-associated protein
- phosphorylated upon DNA damage, probably by ATM or ATR
Pathology:
- antigenic molecule
- may induce anti-centromere antibodies
- autoantibodies against SSSCA1 found in Sjogren's syndrome & scleroderma
Related
p27 Ag in tissue
scleroderma (diffuse cutaneous systemic sclerosis)
Sjogren's syndrome (autoimmune epitheliitis)
General
nuclear protein
phosphoprotein
Properties
SIZE: entity length = 199 aa
MW = 21 kD
COMPARTMENT: cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
acidic region {75-83}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S94}
proline-rich region
SITE: 113-122
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 138-145
MOTIF: proline residue (SEVERAL)
threonine-rich region {170-177}
MOTIF: threonine residue (SEVERAL)
Database Correlations
OMIM 606044
UniProt O60232
Pfam PF06677
Entrez Gene 10534
Kegg hsa:10534
References
UniProt :accession O60232