sister chromatid cohesion protein PDS5 homolog A (sister chromatid cohesion protein 112, SCC-112, cell proliferation-inducing gene 54 protein, PDS5A, KIAA0648, PDS5, PIG54)

Function: - may contribute to regulation of sister chromatid cohesion during mitosis - interacts with the cohesin complex - binds chromatin in a cohesin-dependent manner Structure: - belongs to the PDS5 family - contains 1 HEAT repeat - contains 3 LRR repeats (leucine-rich repeats) Compartment: - nucleus - associated with chromatin through most of the cell cycle - dissociates from chromatin in late prophase, reassociates during late telophase Alternative splicing: named isoforms=3 Expression: - highest level in colon - low levels in lung, ovary, breast & kidney - diminished level in renal tumor tissue - isoform 3 expressed in kidney - cell cycle-regulated with highest level in G2 phase Genetics: - HeLa cells with a diminished level of PDS5A show a mild defect in sister chromatid cohesion. - HeLa cells with a diminished level of RAD21 show diminished association of PDS5A with chromatin

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 1337 aa MW = 151 kD COMPARTMENT: cell nucleus MOTIF: leucine-rich repeat SITE: 243-268 MOTIF: leucine residue (SEVERAL) HEAT repeat {393-429} leucine-rich repeat SITE: 615-638 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 681-704 MOTIF: leucine residue (SEVERAL) Thr phosphorylation site {T1208} Ser phosphorylation site {S1305}

Database Correlations

UniProt Q29RF7 Pfam PF02985

References

UniProt :accession Q29RF7