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miR-34a
Pathology:
- miR-34a nhibits osteoclasts & (to a lesser extent) stimulates osteoblasts [1]
Comparative biology:
- human & mouse miR-34a are identical
- mice engineered to overexpress miR-34a
- exhibit high bone mass
- are less likely than control mice to develop osteoporosis after ovariectomy
- have fewer bony metastases after inoculation with a mouse melanoma cell line or a human breast cancer cell line [1]
* a nanoparticle that mimics the action of miR-34a attenuates both osteoporosis & bony metastases in mice [1]
General
small non coding rna
Properties
FORM: miR-34a
References
- Rayner KJ et al.
Inhibition of miR-33a/b in non-human primates raises plasma
HDL and lowers VLDL triglycerides.
Nature 2011 Oct 20; 478:404
PMID: 22012398