miR-132

Function: - suppresses expression of p120RasGAP - increases Ras activity - increases proliferation of endothelial cells & increases their tube-formining capacity (increases angiogenesis) - acts as an angiogenic switch by suppressing endothelial p120RasGAP expression, leading to Ras activation & neovascularization Expression: - highly expressed in the endothelium of human tumors & hemangiomas - undetectable in normal endothelium

Properties

FORM: miR-132

References

- Anand S et al. MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis. Nat Med 2010 Aug; 16:909. PMID: 20676106