single-strand selective monofunctional uracil DNA glycosylase

Function: 1) recognizes base lesions in the genome 2) initiates base excision DNA repair 3) monofunctional DNA glycosylase specific for uracil (U) residues in DNA 4) preference for single-stranded DNA substrates 5) activity is greater against mismatches (U/G) than against matches (U/A) 6) excises uracil, 5-formyluracil & uracil derivatives with an oxidized group at C5 [5-hydroxyuracil & 5-hydroxy- methyluracil] in ssDNA & dsDNA Compartment: nucleus Alternative splicing: named isoforms=2

Properties

SIZE: MW = 30 kD entity length = 270 aa COMPARTMENT: cell nucleus MOTIF: binding site SITE: 84-84 FOR-BINDING-OF: Substrate binding site SITE: 98-98 FOR-BINDING-OF: Substrate binding site SITE: 163-163 FOR-BINDING-OF: Substrate DNA-binding motif SITE: 173-187 binding site SITE: 239-239 FOR-BINDING-OF: Substrate

Database Correlations

OMIM 607753 UniProt Q53HV7

References

UniProt :accession Q53HV7