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single-stranded DNA-binding protein 3 (sequence-specific single-stranded-DNA-binding protein, SSBP3, SSDP, SSDP1)
Function:
- role in transcription regulation of collagen-1 alpha-2 gene where it binds to single-stranded polypyrimidine sequences in the promoter region
Structure:
- contains 1 LisH domain
Compartment: nucleus
Alternative splicing: named isoforms=3
Expression:
- highly expressed in all hematopoietic tissues, including spleen, lymph node, peripheral blood, bone marrow, thymus, & fetal liver
- highest expression in thymus & fetal liver
- expression is also high in heart, brain, kidney, & skeletal muscle
General
DNA-binding protein
Properties
SIZE: MW = 40 kD
entity length = 388 aa
COMPARTMENT: cell nucleus
MOTIF: LisH {16-48}
proline-rich region
SITE: 98-319
MOTIF: proline residue (SEVERAL)
glycine-rich region {158-369}
Database Correlations
OMIM 607390
UniProt Q9BWW4
Pfam PF04503
References
UniProt :accession Q9BWW4