RNA-binding motif, single-stranded-interacting protein 1; single-stranded DNA-binding protein MSSP-1; suppressor of CDC2 with RNA-binding motif 2 (RBMS1, MSSP, MSSP1, SCR2)

Function: - single-stranded DNA binding protein - interacts with region upstream of the C-myc gene - binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3' - probably has a role in DNA replication Structure: contains 2 RRM domain (RNA recognition motif)s Compartment: nucleus Alternative splicing: named isoforms=3 Expression: - highest amounts are found in placenta, lung & heart - expressed at highest levels during the G1 to S phase transition of the cell cycle

General

nuclear protein phosphoprotein single-stranded DNA-binding protein

Properties

SIZE: entity length = 406 aa MW = 45 kD COMPARTMENT: cell nucleus MOTIF: RNP motif NAME: RNP motif SITE: 62-135 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S112} RNP motif NAME: RNP motif SITE: 141-226 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Thr phosphorylation site {T208}

Database Correlations

OMIM 602310 UniProt P29558 Pfam PF00076 Entrez Gene 5937 Kegg hsa:5937

References

UniProt :accession P29558