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single Ig IL-1-related receptor; single Ig IL-1R-related molecule; single immunoglobulin domain-containing IL1R-related protein; Toll/interleukin-1 receptor 8; TIR8 (SIGIRR)
Function:
1) negative regulator of Toll-like receptor & IL1R signaling
2) attenuates recruitment of receptor-proximal signaling components to the TLR4 receptor
3) interferes with heterodimerization of Il1R1 & IL1RAP
4) interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9, TRAF6
5) upon IL-1 stimulation found in a complex of: IL1R1, SIGIRR, MYD88, IRAK1, TRAF6
6) upon stimulation with LPC found in a complex of: TLR4, SIG1IR, MYD88, IRAK1, TRAF6.
Structure:
- belongs to the interleukin-1 receptor family
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 TIR domain
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in epithelial tissues, kidney, lung, gut
General
cell surface receptor
glycoprotein
phosphoprotein
Properties
SIZE: entity length = 410 aa
MW = 46 kD
COMPARTMENT: plasma membrane
MOTIF: immunoglobulin superfamily domain {9-109}
MOTIF: N-glycosylation site {N31}
cysteine residue {C32}
MODIFICATION: cysteine residue {C98}
N-glycosylation site {N73}
N-glycosylation site {N86}
cysteine residue {C98}
MODIFICATION: cysteine residue {C32}
N-glycosylation site {N102}
transmembrane domain {119-139}
TIR domain {163-310}
Ser phosphorylation site {S380}
Database Correlations
OMIM 605478
UniProt Q6IA17
Pfam PF01582
Kegg hsa:5930
References
UniProt :accession Q6IA17