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Sin3A corepressor complex
Structure:
- subunits: SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 & HDAC2
Note: unclear if this is the same as sin3 repressor complex
Related
sin3 repressor complex
General
molecular complex
Properties
SUBUNITS: paired amphipathic helix protein sin3a
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S10}
HCFC1 interaction {119-196}
MOTIF: paired amphipathic helix {119-189}
REST interaction {205-480}
MOTIF: proline-rich region
SITE: 218-285
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S277}
Ser phosphorylation site {S289}
paired amphipathic helix {300-383}
paired amphipathic helix {456-525}
MOTIF: SAP30 interaction {458-525}
NCOR1 interaction {523-850}
MOTIF: SUDS3/SAP130 interaction {524-659}
HDAC1/ARID4B interaction {687-829}
Ser phosphorylation site {S832}
glutamate-rich region {835-841}
MOTIF: glutamate residue (SEVERAL)
Ser phosphorylation site {S860}
OGT interaction {888-967}
MOTIF: coiled coil {903-932}
Ser phosphorylation site {S940}
Ser phosphorylation site {S1108}
Ser phosphorylation site {S1112}
histone deacetylase complex subunit SAP130
COMPARTMENT: cell nucleus
MOTIF: serine-rich region {81-85}
MOTIF: serine residue (SEVERAL)
proline-rich region
SITE: 124-169
MOTIF: proline residue (SEVERAL)
alanine-rich region {234-238}
MOTIF: alanine residue (SEVERAL)
proline-rich region
SITE: 709-836
MOTIF: proline residue (SEVERAL)
SIN3A & HDAC1 interactions {836-1047}
Sin3 histone deacetylase corepressor complex component SDS3
MOTIF: coiled coil {66-171}
Sin3 interaction {188-226}
AT-rich interactive domain-containing protein 4B
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: serine-rich region {154-159}
MOTIF: serine residue (SEVERAL)
glutamate-rich region {268-567}
MOTIF: glutamate residue (SEVERAL)
ARID {306-398}
Antigenic epitope {465-473}
Ser phosphorylation site {S710}
Ser phosphorylation site {S712}
Ser phosphorylation site {S713}
Ser phosphorylation site {S717}
coiled coil {728-754}
Thr phosphorylation site {T1022}
Ser phosphorylation site {S1029}
serine-rich region {1095-1101}
MOTIF: serine residue (SEVERAL)
Antigenic epitope {1130-1137}
coiled coil {1231-1270}
serine-rich region {1271-1303}
MOTIF: serine residue (SEVERAL)
histone deacetylase 1
COMPARTMENT: cell nucleus
MOTIF: Histone deacetylase {9-321}
MOTIF: histidine residue {H141}
Tyr phosphorylation site {Y221}
Ser phosphorylation site {S393}
Ser phosphorylation site {S421}
Ser phosphorylation site {S423}
binding site
FOR-BINDING-OF: retinoblastoma-associated protein
histone deacetylase 2
COMPARTMENT: cell nucleus
MOTIF: Histone deacetylase {9-322}
MOTIF: histidine residue {H142}
glycine-rich region {300-303}
Ser phosphorylation site {S394}
Ser phosphorylation site {S407}
Ser phosphorylation site {S422}
Ser phosphorylation site {S424}
References
- UniProt :accession Q4LE39
Components
AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B, histone deacetylase complex subunit SAP180, 180 kD Sin3-associated polypeptide, Sin3-associated polypeptide p180, Retinoblastoma-binding protein 1-like 1, breast cancer-associated antigen BRCAA1, ARID4B, BRCAA1, RBBP1L1, RBP1L1, SAP180)
histone deacetylase 1 (reduced potassium dependency 3 [RPD3] homolog-like 1, HDAC1, RPD3L1)
histone deacetylase 2 (HDAC2)
histone deacetylase complex subunit SAP130 (130 kD Sin3-associated polypeptide, Sin3-associated polypeptide p130, SAP130)
paired amphipathic helix protein sin3a; murine yeast transcription repressor Sin3 homolog; transcriptional corepressor Sin3a; histone deacetylase complex subunit Sin3a (SIN3A, mSin3A)
Sin3 histone deacetylase corepressor complex component SDS3 (suppressor of defective silencing 3 protein homolog, SUDS3, SDS3, SAP45)