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silent brain infarct

Epidemiology: 28% of individuals, mean age of 75 years Radiology: detected by magnetic resonance imaging (MRI) Complications: - nearly twice as likely to develop symptomatic stroke than those without infarcts (7.3% vs 3.8% within 4 years) [1] - multiple silent infarcts further increase risk of symptomatic stroke (9.6% for multiple vs 5.9% for single silent infarct) [1] - 2-3 fold risk of ischemic stroke within 15 years [2] - associated with cognitive dysfunction [3]

Related

ischemic stroke

General

stroke; cerebrovascular accident (CVA)

References

  1. Journal Watch 21(22):178, 2001 - Bernick C, Kuller L, Dulberg C et al Silent MRI infarcts and the risk of future stroke: the cardiovascular health study. Neurology. 2001 Oct 9;57(7):1222-9. PMID: 11591840
  2. Orciari Herman A, Hefner JE Silent Brain Infarction Associated with Increased Risk for Future Stroke. Physician's First Watch, Feb 18, 2016 David G. Fairchild, MD, MPH, Editor-in-Chief Massachusetts Medical Society http://www.jwatch.org - Gupta A, Giambrone AE, Gialdini G et al Silent Brain Infarction and Risk of Future Stroke. A Systematic Review and Meta-Analysis. Stroke. Feb 17, 2016 PMID: 26888534 http://stroke.ahajournals.org/content/early/2016/02/17/STROKEAHA.115.011889
  3. Anand SS, Friedrich MG, Desai D et al. Reduced cognitive assessment scores among individuals with magnetic resonance imaging-detected vascular brain injury. Stroke 2020 Apr; 51:1158. PMID: 32126938 https://www.ahajournals.org/doi/10.1161/STROKEAHA.119.028179