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translocon-associated protein subunit alpha; TRAP-alpha; signal sequence receptor subunit alpha; SSR-alpha (SSR1, TRAPA, PSEC0262)
Function:
- subunit of signal sequence receptor whose function is to bind Ca+2 to the ER membrane & thus regulate retention of ER resident proteins
- may be involved in recycling of the translocation apparatus
- may function as a membrane-bound chaperone facilitating folding of translocated proteins
- phosphorylated in its cytoplasmic tail (putative)
- seems to bind Ca+2
Structure:
- bipoar molecule:
- negatively charged N-terminus
- positively charged C-terminus
- belongs to the TRAP-alpha family
Compartment:
- endoplasmic reticulum membrane
Alternative splicing: named isoforms=2
General
glycoprotein
membrane protein
phosphoprotein
protein subunit
Properties
SIZE: entity length = 286 aa
MW = 32 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: signal sequence {1-18}
N-glycosylation site {N136}
N-glycosylation site {N191}
transmembrane domain {208-228}
Ser phosphorylation site {S247}
Thr phosphorylation site {T260}
Ser phosphorylation site {S268}
Database Correlations
OMIM 600868
UniProt P43307
Pfam PF03896
Entrez Gene 6745
Kegg hsa:6745
References
- UniProt :accession P43307
- OMIM :accession 600868
Component-of
endoplasmic reticulum signal sequence receptor (SSR, translocon-associated protein, TRAP)