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endoplasmic reticulum signal sequence receptor (SSR, translocon-associated protein, TRAP)
Function:
- binding of Ca+2 to the endoplasmic reticulum (ER) membrane & thus regulate retention of ER resident proteins
Structure:
- heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta & TRAP-gamma
Compartment: endoplasmic reticulum membrane
General
glycoprotein
membrane protein
multisubunit protein
phosphoprotein
Properties
COMPARTMENT: endoplasmic reticulum
MOTIF: glycosylation site
membrane region
phosphorylation site
SUBUNITS: translocon-associated protein subunit alpha
MOTIF: signal sequence {1-18}
N-glycosylation site {N136}
N-glycosylation site {N191}
transmembrane domain {208-228}
Ser phosphorylation site {S247}
Thr phosphorylation site {T260}
Ser phosphorylation site {S268}
translocon-associated protein subunit beta
MOTIF: signal sequence {1-17}
N-glycosylation site {N88}
N-glycosylation site {N104}
transmembrane domain {150-169}
signal sequence receptor-gamma
MOTIF: exoplasmic domain {1-27}
MOTIF: Ser phosphorylation site {S11}
transmembrane domain {28-48}
cytoplasmic loop {49-54}
transmembrane domain {55-76}
exoplasmic loop {77-135}
MOTIF: Ser phosphorylation site {S105}
transmembrane domain {136-157}
cytoplasmic loop {158-163}
transmembrane domain {164-184}
translocon-associated protein subunit delta
MOTIF: signal sequence {1-23}
cysteine residue {C26}
MODIFICATION: cysteine residue {C57}
cysteine residue {C57}
MODIFICATION: cysteine residue {C26}
transmembrane domain {145-165}
References
- Ou WJ et al
Association of folding intermediates of glycoproteins with
calnexin during protein maturation.
Nature 364:771 1993
PMID: 8102790
- UniProt :accession P43307
UniProt :accession P43308
UniProt :accession Q9UNL2
UniProt :accession P51571
Components
signal sequence receptor-gamma (SSR-gamma, translocon-associated protein gamma subunit, TRAP-gamma)
translocon-associated protein subunit alpha; TRAP-alpha; signal sequence receptor subunit alpha; SSR-alpha (SSR1, TRAPA, PSEC0262)
translocon-associated protein subunit beta; TRAP-beta; signal sequence receptor subunit beta; SSR-beta (SSR2, TRAPB, HSD25)
translocon-associated protein subunit delta; TRAP-delta; signal sequence receptor subunit delta; SSR-delta (SSR4, TRAPD)