signal sequence (signal peptide)

The endoplasmic reticulum (ER) signal sequence of proteins destined for the secretory pathway marks proteins for translocation across the endoplasmic reticulum membrane. These signal sequences are generally at the N-terminus & absent from the mature proteins because they are cleaved by a signal peptidase within the lumenal side of the ER. They range in size from 13-36 amino acid residues.

General

peptide motif polypeptide sequence

References

Stryer Biochemistry WH Freeman & Co, New York, 1988 pg 768-772