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signal-regulatory protein beta-1; SIRP-beta-1; CD172 antigen-like family member B; CD172b (SIRPB1)
Function:
- immunoglobulin-like cell surface receptor involved in negative regulation of receptor tyrosine kinase-coupled signaling processes
- also participates in recruitment of tyrosine kinase SYK
- interacts with TYROBP; interaction results in recruitment of SYK
Structure:
- N-glycosylated
- contains 2 Ig-like C1-type (immunoglobulin-like) domains
- contains 1 Ig-like V-type domain
Compartment:
- membrane; single-pass type 1 membrane protein
Alternative splicing: named isoforms=3
Expression:
- expressed in monocytes & dendritic cells
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
signal-regulatory protein-beta (SIRP-beta)
Properties
SIZE: MW = 43 kD
entity length = 398 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-26}
immunoglobulin superfamily domain {27-136}
MOTIF: cysteine residue {C54}
MODIFICATION: cysteine residue {C120}
cysteine residue {C120}
MODIFICATION: cysteine residue {C54}
immunoglobulin superfamily domain {147-246}
MOTIF: cysteine residue {C169}
MODIFICATION: cysteine residue {C227}
cysteine residue {C227}
MODIFICATION: cysteine residue {C169}
N-glycosylation site {N244}
immunoglobulin superfamily domain {253-347}
MOTIF: N-glycosylation site {N269}
cysteine residue {C272}
MODIFICATION: cysteine residue {C320}
N-glycosylation site {N291}
cysteine residue {C320}
MODIFICATION: cysteine residue {C272}
transmembrane domain {372-392}
Database Correlations
OMIM 603889
UniProt O00241
PFAM correlations
Entrez Gene 10326
Kegg hsa:10326
References
UniProt :accession O00241