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signal recognition particle
SRP has the shape of a rod, 24 nm long & 5 nm wide with 7SL rRNA forming the backbone of the molecule. SRP binds nascent peptides destined for the ER/GOLGI, halts elongation & delivers intact peptide/80S elongation complex to the endoplasmic reticulum.
Related
signal recognition particle Ab in serum/plasma
signal recognition peptide [SRP] receptor or docking protein
General
molecular complex
nucleoprotein
Properties
SIZE: MW = 325 kD
SUBUNITS: signal recognition particle 9 kD subunit (SRP9)
signal recognition particle 14 kD subunit (SRP14)
signal recognition particle 19 kD subunit (SRP19)
MOTIF: RNA-binding motif
SITE: 136-144
FOR-BINDING-OF: ribonucleic acid
signal recognition particle 54 kD subunit (SRP54)
MOTIF: G domain {1-295}
MOTIF: GTP-binding site
SITE: 108-115
GTP-binding site
SITE: 190-194
GTP-binding site
SITE: 248-251
M domain {296-504}
MOTIF: binding site
FOR-BINDING-OF: 7SL rRNA
binding site
FOR-BINDING-OF: signal sequence
signal recognition particle 68 kD subunit (SRP68)
MOTIF: glycine residue {9-24} (16)
signal recognition particle 72 kD subunit (SRP72)
MOTIF: tetratricopeptide repeat {10-43}
tetratricopeptide repeat {108-141}
tetratricopeptide repeat {225-258}
tetratricopeptide repeat {405-438}
tetratricopeptide repeat {446-479}
lysine residue {551-560} (10)
lysine residue {661-664} (4)
7SL rRNA
References
- Bourne HR et al,
The GTPase superfamily: a conserved switch for diverse cell
functions
Nature 348:125 1990
PMID: 2122258
- Stryer Biochemistry WH Freeman & Co, New York, 1988 pg 770
Components
7SL rRNA
signal recognition particle 14 kD subunit (SRP14)
signal recognition particle 19 kD subunit (SRP19)
signal recognition particle 54 kD subunit (SRP54)
signal recognition particle 68 kD subunit (SRP68)
signal recognition particle 72 kD subunit (SRP72)
signal recognition particle 9 kD subunit (SRP9)