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signal peptide peptidase-like 2C (protein SPP-like 2C, protein SPPL2c, intramembrane protease 5, IMP5, SPPL2C IMP5)
Function:
- may act as intramembrane protease (putative)
Structure: belongs to the peptidase A22B family
Compartment: membrane
General
aspartic proteinase; carboxyl acid protease
glycoprotein
transmembrane 8e protein
Properties
SIZE: entity length = 684 aa
MW = 74 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-186}
MOTIF: signal sequence {1-21}
N-glycosylation site {N100}
transmembrane domain {187-207}
cytoplasmic loop {208-253}
transmembrane domain {254-274}
exoplasmic loop {275-276}
transmembrane domain {277-297}
cytoplasmic loop {298-319}
transmembrane domain {320-340}
exoplasmic loop {341-376}
transmembrane domain {377-397}
MOTIF: aspartate residue {D386}
cytoplasmic loop {398-439}
transmembrane domain {440-460}
MOTIF: aspartate residue {D448}
exoplasmic loop {461-472}
transmembrane domain {473-493}
cytoplasmic loop {494-495}
transmembrane domain {496-516}
exoplasmic domain {517-684}
Database Correlations
OMIM 608284
UniProt Q8IUH8
Pfam PF04258
Kegg hsa:1625
References
UniProt :accession Q8IUH8