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signal peptide, CUB & EGF-like domain-containing protein 3 (SCUBE3, CEGF3)
Function:
- forms homo-oligomers & hetero-oligomers with SCUBE1
- may undergo proteolytic cleavage in the C-terminal region
Compartment: secreted, cell surface
Alternative splicing: named isoforms=2
Expression:
- highly expressed in osteoblasts
- expression is low or absent in non-bone tissues
Structure:
- N-glycosylated
- contains 1 CUB domain
- contains 9 EGF-like domains
Related
signal peptide, CUB & EGF-like domain-containing protein
General
EGF-like domain-containing protein (EGFL)
glycoprotein
secreted protein
Properties
SIZE: MW = 109 kD
entity length = 993 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
EGF domain {29-69}
MOTIF: cysteine residue {C33}
MODIFICATION: cysteine residue {C46}
cysteine residue {C40}
MODIFICATION: cysteine residue {C55}
cysteine residue {C46}
MODIFICATION: cysteine residue {C33}
cysteine residue {C55}
MODIFICATION: cysteine residue {C40}
cysteine residue {C57}
MODIFICATION: cysteine residue {C68}
cysteine residue {C68}
MODIFICATION: cysteine residue {C57}
EGF domain {70-111}
MOTIF: cysteine residue {C74}
MODIFICATION: cysteine residue {C86}
cysteine residue {C82}
MODIFICATION: cysteine residue {C95}
cysteine residue {C86}
MODIFICATION: cysteine residue {C74}
cysteine residue {C95}
MODIFICATION: cysteine residue {C82}
cysteine residue {C97}
MODIFICATION: cysteine residue {C110}
cysteine residue {C110}
MODIFICATION: cysteine residue {C97}
EGF domain {112-148}
MOTIF: cysteine residue {C116}
MODIFICATION: cysteine residue {C127}
cysteine residue {C123}
MODIFICATION: cysteine residue {C136}
cysteine residue {C127}
MODIFICATION: cysteine residue {C116}
cysteine residue {C136}
MODIFICATION: cysteine residue {C123}
EGF domain {157-198}
MOTIF: cysteine residue {C161}
MODIFICATION: cysteine residue {C172}
cysteine residue {C168}
MODIFICATION: cysteine residue {C182}
cysteine residue {C172}
MODIFICATION: cysteine residue {C161}
cysteine residue {C182}
MODIFICATION: cysteine residue {C168}
cysteine residue {C184}
MODIFICATION: cysteine residue {C197}
cysteine residue {C197}
MODIFICATION: cysteine residue {C184}
EGF domain {199-237}
MOTIF: cysteine residue {C201}
MODIFICATION: cysteine residue {C212}
cysteine residue {C208}
MODIFICATION: cysteine residue {C221}
cysteine residue {C212}
MODIFICATION: cysteine residue {C201}
cysteine residue {C221}
MODIFICATION: cysteine residue {C208}
cysteine residue {C223}
MODIFICATION: cysteine residue {C236}
cysteine residue {C236}
MODIFICATION: cysteine residue {C223}
EGF domain {238-276}
MOTIF: cysteine residue {C240}
MODIFICATION: cysteine residue {C251}
cysteine residue {C247}
MODIFICATION: cysteine residue {C260}
cysteine residue {C251}
MODIFICATION: cysteine residue {C240}
cysteine residue {C260}
MODIFICATION: cysteine residue {C247}
cysteine residue {C262}
MODIFICATION: cysteine residue {C275}
cysteine residue {C275}
MODIFICATION: cysteine residue {C262}
EGF domain {277-317}
MOTIF: cysteine residue {C281}
MODIFICATION: cysteine residue {C292}
cysteine residue {C288}
MODIFICATION: cysteine residue {C301}
cysteine residue {C292}
MODIFICATION: cysteine residue {C281}
cysteine residue {C301}
MODIFICATION: cysteine residue {C288}
cysteine residue {C303}
MODIFICATION: cysteine residue {C316}
cysteine residue {C316}
MODIFICATION: cysteine residue {C303}
EGF domain {318-356}
MOTIF: cysteine residue {C322}
MODIFICATION: cysteine residue {C332}
cysteine residue {C328}
MODIFICATION: cysteine residue {C341}
cysteine residue {C332}
MODIFICATION: cysteine residue {C322}
cysteine residue {C341}
MODIFICATION: cysteine residue {C328}
cysteine residue {C343}
MODIFICATION: cysteine residue {C355}
cysteine residue {C355}
MODIFICATION: cysteine residue {C343}
EGF domain {357-398}
MOTIF: cysteine residue {C361}
MODIFICATION: cysteine residue {C372}
cysteine residue {C368}
MODIFICATION: cysteine residue {C381}
cysteine residue {C372}
MODIFICATION: cysteine residue {C361}
cysteine residue {C381}
MODIFICATION: cysteine residue {C368}
cysteine residue {C383}
MODIFICATION: cysteine residue {C397}
cysteine residue {C397}
MODIFICATION: cysteine residue {C383}
N-glycosylation site {N417}
N-glycosylation site {N464}
N-glycosylation site {N685}
N-glycosylation site {N756}
N-glycosylation site {N785}
CUB domain {804-916}
MOTIF: cysteine residue {C804}
MODIFICATION: cysteine residue {C830}
cysteine residue {C830}
MODIFICATION: cysteine residue {C804}
cysteine residue {C857}
MODIFICATION: cysteine residue {C878}
cysteine residue {C878}
MODIFICATION: cysteine residue {C857}
Database Correlations
UniProt Q8IX30
PFAM correlations
References
UniProt :accession Q8IX30