signal peptide, CUB & EGF-like domain-containing protein 1 (SCUBE1)

Function: - adhesive molecule (putative) - matrix bound & soluble fragments may play role in vascular system - forms homo-oligomers & hetero-oligomers with SCUBE2 & SCUBE3 - Could be proteolytically cleaved to release a smaller active fragment Structure: - N-glycosylated - contains 1 CUB domain - contains 9 EGF-like domains Compartment: - secreted, cell membrane, peripheral membrane - stored in platelet alpha granules, transferred to the cell surface upon activation and aggregation Expression: - expressed in endothethelial cells, platelets - down-regulated by inflammatory cytokines Pathology: - smaller form, probably produced by limited proteolysis, after being released from the storage granules, is associated with thrombus & localized with the subendothelial matrices in atherosclerotic plaques

General

EGF-like domain-containing protein (EGFL) glycoprotein membrane protein secreted protein

Properties

SIZE: MW = 108 kD entity length = 988 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-23} EGF domain {33-73} MOTIF: cysteine residue {C37} MODIFICATION: cysteine residue {C50} cysteine residue {C44} MODIFICATION: cysteine residue {C59} cysteine residue {C50} MODIFICATION: cysteine residue {C37} cysteine residue {C59} MODIFICATION: cysteine residue {C44} cysteine residue {C61} MODIFICATION: cysteine residue {C72} cysteine residue {C72} MODIFICATION: cysteine residue {C61} EGF domain {74-116} MOTIF: cysteine residue {C78} MODIFICATION: cysteine residue {C91} cysteine residue {C87} MODIFICATION: cysteine residue {C100} cysteine residue {C91} MODIFICATION: cysteine residue {C78} cysteine residue {C100} MODIFICATION: cysteine residue {C87} cysteine residue {C102} MODIFICATION: cysteine residue {C115} cysteine residue {C115} MODIFICATION: cysteine residue {C102} EGF domain {117-153} MOTIF: cysteine residue {C121} MODIFICATION: cysteine residue {C132} cysteine residue {C128} MODIFICATION: cysteine residue {C141} cysteine residue {C132} MODIFICATION: cysteine residue {C121} cysteine residue {C141} MODIFICATION: cysteine residue {C128} EGF domain {166-202} EGF domain {238-276} EGF domain {245-280} EGF domain {282-322} MOTIF: cysteine residue {C286} MODIFICATION: cysteine residue {C297} cysteine residue {C293} MODIFICATION: cysteine residue {C306} cysteine residue {C297} MODIFICATION: cysteine residue {C286} cysteine residue {C306} MODIFICATION: cysteine residue {C293} cysteine residue {C308} MODIFICATION: cysteine residue {C321} cysteine residue {C321} MODIFICATION: cysteine residue {C308} EGF domain {323-361} MOTIF: cysteine residue {C327} MODIFICATION: cysteine residue {C337} cysteine residue {C333} MODIFICATION: cysteine residue {C346} cysteine residue {C337} MODIFICATION: cysteine residue {C327} cysteine residue {C346} MODIFICATION: cysteine residue {C333} cysteine residue {C348} MODIFICATION: cysteine residue {C360} cysteine residue {C360} MODIFICATION: cysteine residue {C348} EGF domain {362-402} MOTIF: cysteine residue {C366} MODIFICATION: cysteine residue {C377} N-glycosylation site {N370} cysteine residue {C373} MODIFICATION: cysteine residue {C386} cysteine residue {C377} MODIFICATION: cysteine residue {C366} cysteine residue {C386} MODIFICATION: cysteine residue {C373} cysteine residue {C388} MODIFICATION: cysteine residue {C401} cysteine residue {C401} MODIFICATION: cysteine residue {C388} N-glycosylation site {N466} N-glycosylation site {N679} N-glycosylation site {N750} N-glycosylation site {N779} N-glycosylation site {N789} CUB domain {798-910} MOTIF: cysteine residue {C798} MODIFICATION: cysteine residue {C824} cysteine residue {C824} MODIFICATION: cysteine residue {C798} cysteine residue {C851} MODIFICATION: cysteine residue {C872} cysteine residue {C872} MODIFICATION: cysteine residue {C851}

Database Correlations

UniProt Q8IWY4 PFAM correlations

References

UniProt :accession Q8IWY4