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signal peptidase complex
Function:
- cleaves signal peptides from N-terminus of nascent proteins destined for the secretory pathway after translocation into the lumen of the endoplasmic reticulum
Structure:
- complex of five different proteins:
- SPC25, SPC22/23, SPC21, SPC18, & SPC12
Compartment:
- endoplasmic reticulum
General
molecular complex
protease; proteinase; endopeptidase
Properties
COMPARTMENT: endoplasmic reticulum
MOTIF: active site
SUBUNITS: kinetochore protein Spc25
COMPARTMENT: cell nucleus
MOTIF: SPBC24 interaction {1-144}
MOTIF: KNTC2-NUF2 interaction {1-56}
coiled coil {61-142}
SPBC24 interaction {145-224}
signal peptidase complex 22/23KD subunit
MOTIF: transmembrane domain {12-32}
N-glycosylation site {N141}
hydrophobic domain {144-164}
signal peptidase complex 21KD subunit
MOTIF: transmembrane domain {28-47}
serine residue {S67}
hydrophobic domain {156-167}
signal peptidase complex 18KD subunit
MOTIF: transmembrane domain {17-36}
serine residue {S56}
hydrophobic domain {144-176}
signal peptidase complex 12D subunit
MOTIF: cytoplasmic domain {1-19}
transmembrane domain {20-42}
exoplasmic loop {43-46}
transmembrane domain {47-69}
cytoplasmic domain {70-102}
References
UniProt :accession P50454, P21378, Q9BY50, P61009, Q15005
Components
kinetochore protein Spc25 (hSpc25, SPC25, SPBC25, AD024)
signal peptidase complex 12KD subunit (signal peptidase complex subunit 1, SPase 12 kD subunit, SPCS1, SPC12, HSPC033)
signal peptidase complex 18KD subunit (signal peptidase complex catalytic subunit SEC11A, SEC11 homolog A, SEC11-like protein 1, SPase 18 kD subunit, SPC18, endopeptidase SP18, SEC11A, SEC11L1, SPC18)
signal peptidase complex 21KD subunit (signal peptidase complex catalytic subunit SEC11C, SEC11 homolog C, SEC11-like protein 3, microsomal signal peptidase 21 kD subunit, SPase 21 kD subunit, SPC21, SEC11C, SEC11L3)
signal peptidase complex 22/23KD subunit (signal peptidase complex subunit 3, microsomal signal peptidase 23 kD subunit, SPase 22 kD subunit, SPCS3, SPC22/23, UNQ1841/PRO3567)