signal-induced proliferation-associated protein 1; Sipa-1; GTPase-activating protein Spa-1; p130 SPA-1 (SIPA1, SPA1)

Function: - GTPase activator for the nuclear Ras-related regulatory proteins rap1 & rap2 in vitro, converting them to the inactive GDP-bound state (putative) Structure: - contains 1 PDZ domain (DHR domain) - contains 1 rap-GAP domain Compartment: - nucleus. cytoplasm, perinuclear region endomembrane system; peripheral membrane protein - mostly localized in the perinuclear membraneous region Expression: - expressed in fetal as well as in adult tissues - expressed abundantly in the lymphoid tissues such as thymus, spleen & peripheral blood lymphocytes - also expressed in spinal cord - expression inhibited by 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells

General

nuclear protein rap GTPase-activating protein (rap-GAP)

Properties

SIZE: entity length = 1042 aa MW = 112 kD COMPARTMENT: cytoplasm nuclear membrane MOTIF: Ser phosphorylation site {S53} Ser phosphorylation site {S55} Thr phosphorylation site {T64} Ser phosphorylation site {S67} Ser phosphorylation site {S74} rap-GAP domain NAME: rap-GAP domain SITE: 321-539 PDZ domain NAME: PDZ domain SITE: 687-763 Ser phosphorylation site {S839} coiled coil {972-1034}

Database Correlations

OMIM 602180 UniProt Q96FS4 PFAM correlations Entrez Gene 6494 Kegg hsa:6494

References

UniProt :accession Q96FS4