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signaling threshold-regulating transmembrane adapter 1 (SHP2-interacting transmembrane adapter protein, gp30/40, SIT1, SIT)
Function:
1) negatively regulates TCR-mediated signaling in T-cells
2) positive selection of T-cells
3) phosphorylated on TYR by LCK, FYN or ZAP70 upon TCR activation
4) when phosphorylated, interacts with PTPN11/SHP2, GRB2, CSK
Structure: homodimer, disulfide-linked
Compartment: cell membrane
Expression:
- expressed in T-cells & B-cells
- expressed in plasma cells but not in germinal center B-cells
Pathology:
1) expressed in T-cell lymphoma, B-cell lymphoma
General
glycoprotein
oligomerizing protein
phosphoprotein
Properties
CONFIGURATION: dimer
SIZE: MW = 21 kD
entity length = 196 aa
MOTIF: signal sequence {1-24}
N-glycosylation site {N26}
cysteine residue {C27}
MODIFICATION: cysteine residue {C27}
transmembrane domain {41-61}
Ser phosphorylation site {S80}
Ser phosphorylation site {S83}
binding site
SITE: 90-93
FOR-BINDING-OF: growth factor receptor-bound protein-2 (grb2)
MOTIF: Tyr phosphorylation site {Y90}
Tyr phosphorylation site {Y95}
Thr phosphorylation site {T98}
Ser phosphorylation site {S102}
Tyr phosphorylation site {Y127}
Thr phosphorylation site {T144}
binding site
SITE: 146-151
FOR-BINDING-OF: protein tyrosine phosphatase 11
MOTIF: Tyr phosphorylation site {Y148}
Ser phosphorylation site {S149}
binding site
SITE: 169-172
FOR-BINDING-OF: c-src kinase
MOTIF: Tyr phosphorylation site {Y169}
Ser phosphorylation site {S182}
binding site
SITE: 188-191
FOR-BINDING-OF: growth factor receptor-bound protein-2 (grb2)
MOTIF: Tyr phosphorylation site {Y188}
Database Correlations
OMIM 604964
UniProt Q9Y3P8
References
UniProt :accession Q9Y3P8