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sialyltransferase 8E; alpha-2,8-sialyltransferase 8E (ST8SIA5, SIAT8E)
Function:
- may be involved in the synthesis of gangliosides GD1c, GT1a, GQ1b & GT3 from GD1a, GT1b, GM1b & GD3 respectively
- protein modification; protein glycosylation
Structure: belongs to the glycosyltransferase 29 family
Compartment: Golgi membrane
Expression:
- expressed in fetal & adult brain, adult heart & skeletal muscle
General
glycoprotein
membrane protein
sialyltransferase
Properties
SIZE: MW = 44 kD
entity length = 376 aa
COMPARTMENT: golgi
MOTIF: transmembrane domain {18-38}
catalytic domain
SITE: 39-376
MOTIF: N-glycosylation site {N56}
N-glycosylation site {N96}
cysteine residue {C164}
MODIFICATION: cysteine residue {C313}
N-glycosylation site {N241}
N-glycosylation site {N284}
cysteine residue {C313}
MODIFICATION: cysteine residue {C164}
Database Correlations
OMIM 607162
UniProt O15466
Pfam PF00777
Entrez Gene 29906
References
- UniProt :accession O15466
- GGDB; Note: glycogene database
http://ggdb.muse.aist.go.jp/GGDB/index.jsp