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sialyltransferase 8D; alpha-2,8-polysialyltransferase; CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase (SIAT8D, ST8SIAIV, ST8SIA4)
Function:
- catalyzes the polycondensation of alpha-2,8-linked sialic acid required for the synthesis of polysialic acid present on the embryonic neural cell adhesion molecule (N-CAM), necessary for plasticity of neural cells
- protein modification; protein glycosylation
Structure: belongs to the glycosyltransferase 29 family
Compartment: Golgi membrane
Expression:
- expressed in fetal brain, lung & kidney & in adult heart, spleen & thymus > adult brain, placenta, lung, colon & small intestine & peripheral blood leukocytes
General
glycoprotein
membrane protein
sialyltransferase
Properties
SIZE: MW = 41 kD
entity length = 359 aa
COMPARTMENT: golgi
MOTIF: transmembrane domain {8-20}
catalytic domain
SITE: 21-359
MOTIF: N-glycosylation site {N50}
N-glycosylation site {N74}
N-glycosylation site {N119}
cysteine residue {C142}
MODIFICATION: cysteine residue {C292}
cysteine residue {C156}
MODIFICATION: cysteine residue {C356}
N-glycosylation site {N204}
N-glycosylation site {N219}
cysteine residue {C292}
MODIFICATION: cysteine residue {C142}
N-glycosylation site {N327}
cysteine residue {C356}
MODIFICATION: cysteine residue {C156}
Database Correlations
OMIM 602547
UniProt Q92187
Pfam PF00777
Entrez Gene 7903
Kegg hsa:7903
References
- UniProt :accession Q92187
- GGDB; Note: glycogene database
http://ggdb.muse.aist.go.jp/GGDB/index.jsp