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sialyltransferase 8C; Sia-alpha-2,3-Gal-beta-1,4-GlcNAc-R:alpha 2,8-sialyltransferase; alpha-2,8-sialyltransferase 8C (ST8SIA3)
Function:
- may transfer sialic acid through alpha-2,8-linkages to alpha-2,3-linked & alpha-2,8-linked sialic acid of N-linked oligosaccharides of glycoproteins & glycolipids
- it can form polysialic acid in vitro directly on alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid
- protein modification; protein glycosylation
Structure: belongs to the glycosyltransferase 29 family
Compartment: Golgi membrane
Expression: expressed in fetal & adult brain & fetal liver
General
glycoprotein
membrane protein
sialyltransferase
Properties
SIZE: MW = 44 kD
entity length = 380 aa
COMPARTMENT: golgi
MOTIF: transmembrane domain {10-33}
catalytic domain
SITE: 34-380
MOTIF: N-glycosylation site {N93}
N-glycosylation site {N113}
cysteine residue {C162}
MODIFICATION: cysteine residue {C313}
N-glycosylation site {N206}
cysteine residue {C313}
MODIFICATION: cysteine residue {C162}
Database Correlations
UniProt O43173
Pfam PF00777
Entrez Gene 51046
Kegg hsa:5104
References
- UniProt :accession O43173
- GGDB; Note: glycogene database
http://ggdb.muse.aist.go.jp/GGDB/index.jsp