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sialyltransferase 8B; sialyltransferase X; alpha-2,8-sialyltransferase (ST8SIAII, SIAT8B, ST8SIA2)
Function:
- may transfer sialic acid through alpha-2,8-linkages to the alpha-2,3-linked & alpha-2,6-linked sialic acid of N-linked oligosaccharides of glycoproteins
- may be involved in polysialic acid expression
- protein modification; protein glycosylation
Structure: belongs to the glycosyltransferase 29 family
Compartment: Golgi membrane
Expression:
- highly expressed in fetal brain, kidney & heart & to a much lesser extent in adult heart & thymus
General
glycoprotein
membrane protein
sialyltransferase
Properties
SIZE: MW = 42 kD
entity length = 375 aa
COMPARTMENT: golgi
MOTIF: transmembrane domain {7-23}
catalytic domain
SITE: 24-375
MOTIF: N-glycosylation site {N60}
N-glycosylation site {N72}
N-glycosylation site {N89}
N-glycosylation site {N134}
cysteine residue {C157}
MODIFICATION: cysteine residue {C307}
N-glycosylation site {N219}
N-glycosylation site {N234}
cysteine residue {C307}
MODIFICATION: cysteine residue {C157}
Database Correlations
OMIM 602546
UniProt Q92186
Pfam PF00777
Entrez Gene 8128
Kegg hsa:8128
References
- UniProt :accession Q92186
- GGDB; Note: glycogene database
http://ggdb.muse.aist.go.jp/GGDB/index.jsp