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sialyltransferase 8A; alpha-N-acetyl-neuraminide:alpha-2,8-sialyltransferase; ganglioside GD3/GT3 synthase (ST8SIAI, ST8SIA1)
Function:
- role in the production of GD3 & GT3 from GM3
- protein modification; protein glycosylation
CMP-N-acetylneuraminate +
alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R
CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl- 2,3-beta-D-galactosyl-R
Structure: belongs to the glycosyltransferase 29 family
Compartment: Golgi membrane
Expression:
- strongly expressed in melanoma cell lines, adult & fetal brain & to a lesser extent in adult & fetal lung
General
glycoprotein
membrane protein
sialyltransferase
Properties
SIZE: entity length = 356 aa
MW = 41 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {30-48}
N-glycosylation site {N71}
N-glycosylation site {N119}
cysteine residue {C138}
MODIFICATION: cysteine residue {C287}
N-glycosylation site {N214}
N-glycosylation site {N245}
cysteine residue {C287}
MODIFICATION: cysteine residue {C138}
Database Correlations
OMIM 601123
UniProt Q92185
Entrez Gene 6489
Kegg hsa:6489
ENZYME 2.4.99.8
References
- UniProt :accession Q92185
- GGDB; Note: glycogene database
http://ggdb.muse.aist.go.jp/GGDB/index.jsp