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sialyltransferase 6; N-acetyllactosaminide alpha-2,3-sialyltransferase; CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase; Gal beta-1,3(4) GlcNAc alpha-2,3 sialyltransferase (ST3N, ST3GalII, SIAT6, ST3GAL3)
Function:
- catalyzes the formation of the neuAc-alpha-2,3-gal-beta-1,4-GlcNAc-, neuAc-alpha-2,3-gal-beta-1,3-GlcNAc- or neuAc-alpha-2,3-gal-beta-1,3-galNAc- sequences found in terminal carbohydrate groups of glycoproteins & glycolipids
- highest activity is toward gal-beta-1,3-GlcNAc & the lowest toward gal-beta-1,3-galNAc (putative)
- protein modification; protein glycosylation
- the soluble form derives from the membrane form by proteolytic processing
CMP-N-acetylneuraminate +
beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein
CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N- acetyl-D-glucosaminyl-glycoprotein
Structure: belongs to the glycosyltransferase 29 family
Compartment:
- Golgi, Golgi stack membrane
- secreted
- membrane-bound form in trans cisternae of Golgi
- secreted into the body fluid
Alternative splicing: named isoforms=26
Expression:
- highly expressed in adult skeletal muscle & in all fetal tissues examined & to a much lesser extent in placenta, lung & liver
General
galactosyltransferase
glycoprotein
membrane protein
sialyltransferase
Properties
SIZE: entity length = 375 aa
MW = 42 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {9-28}
N-glycosylation site {N80}
cysteine residue {C160}
MODIFICATION: cysteine residue {C314}
N-glycosylation site {N171}
cysteine residue {C314}
MODIFICATION: cysteine residue {C160}
Database Correlations
OMIM 606494
UniProt Q11203
Pfam PF00777
Entrez Gene 6487
Kegg hsa:6487
ENZYME 2.4.99.6
References
- UniProt :accession Q11203
- GGDB; Note: glycogene database
http://ggdb.muse.aist.go.jp/GGDB/index.jsp