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sialyltransferase 4C; beta-galactoside alpha-2,3-sialyltransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase; alpha-3-N-acetylneuraminyltransferase; alpha-2,3-sialyltransferase; ST3GALIII; alpha 2,3-ST; GAL-NAC6S; STZ (SIAT4C, ST3GAL1, ST3GAL4, SAT-3, ST-4, CGS23)
Function:
- may catalyze formation of the neuAc-alpha-2,3-gal-beta-1,3-galNAc- or neuAc-alpha-2,3-gal-beta-1,3-GlcNAc-sequences found in terminal carbohydrate groups of glycoproteins & glycolipids
- may be involved in biosynthesis of the sialyl Lewis X determinant
- protein modification; protein glycosylation
- the soluble form derives from the membrane form by proteolytic processing
CMP-N-acetylneuraminate + beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminyl-glycoprotein
CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N- acetyl-D-glucosaminyl-glycoprotein
Structure: belongs to the glycosyltransferase 29 family
Compartment:
- Golgi, Golgi stack membrane
- secreted
- membrane-bound form in trans cisternae of Golgi
- secreted into the body fluid
Alternative splicing: named isoforms=5
Expression:
- highly expressed in adult placenta, ovary & testes
General
galactosyltransferase
glycoprotein
membrane protein
sialyltransferase
Properties
SIZE: entity length = 333 aa
MW = 38 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {9-26}
N-glycosylation site {N61}
cysteine residue {C120}
MODIFICATION: cysteine residue {C273}
N-glycosylation site {N131}
cysteine residue {C273}
MODIFICATION: cysteine residue {C120}
N-glycosylation site {N310}
N-glycosylation site {N329}
Database Correlations
OMIM 104240
UniProt Q11206
Pfam PF00777
Entrez Gene 6484
Kegg hsa:6484
ENZYME 2.4.99.4
References
- UniProt :accession Q11206
- GGDB; Note: glycogene database
http://ggdb.muse.aist.go.jp/GGDB/index.jsp