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sialyltransferase 4B; ST3GAL2; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase; beta-galactoside alpha-2,3-sialyltransferase; gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase (SIAT4B)
Function:
- may be responsible for synthesis of the sequence neuAc-alpha-2,3-gal-beta-1,3-galNAc- found in terminal carbohydrate groups of certain glycoproteins, oligosaccharides & glycolipids
- SIAT4A & SIAT4B sialylate the same acceptor substrates but exhibit different Km values
- protein modification; protein glycosylation
- the soluble form derives from the membrane form by proteolytic processing (putative)
CMP-N-acetylneuraminate +
beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R
CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N- acetyl-alpha-D-galactosaminyl-R
Structure: belongs to the glycosyltransferase 29 family
Compartment:
- Golgi, Golgi stack membrane
- secreted
- membrane-bound form in trans cisternae of Golgi
- secreted into the body fluid (putative)
Expression:
- expressed in skeletal muscle & heart >> brain, placenta, liver & pancreas
- scarcely detectable in lung & kidney
General
glycoprotein
membrane protein
sialyltransferase
Properties
SIZE: entity length = 350 aa
MW = 40 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {7-27}
N-glycosylation site {N92}
cysteine residue {C152}
MODIFICATION: cysteine residue {C291}
N-glycosylation site {N211}
cysteine residue {C291}
MODIFICATION: cysteine residue {C152}
Database Correlations
OMIM 607188
UniProt Q16842
Pfam PF00777
Entrez Gene 6483
Kegg hsa:6483
References
- OMIM :accession 607188
- UniProt :accession Q16842
- GGDB; Note: glycogene database
http://ggdb.muse.aist.go.jp/GGDB/index.jsp