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sialyltransferase 3C; sialyltransferase 7D; NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc-alpha-2,6-sialyltransferase IV (SIAT3C, SIAT7D, ST6GALNAC4)
Function:
- role in biosynthesis of ganglioside GD1A from GM1B
- transfers CMP-neuAc with an alpha-2,6-linkage to galNAc residue on neuAc-alpha-2,3-gal-beta-1,3-galNAc of glycoproteins & glycolipids
- prefers glycoproteins to glycolipids
- protein modification; protein glycosylation
CMP-N-acetylneuraminate +
N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)- N-acetyl-D-galactosaminyl-R
CMP + N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl- (1->3)-(N-acetyl-alpha-neuraminyl-(2->6))-N-acetyl-D- galactosaminyl-R
Structure: belongs to the glycosyltransferase 29 family
Compartment: Golgi membrane
Expression: ubiquitous
General
glycoprotein
membrane protein
sialyltransferase
Properties
SIZE: entity length = 302 aa
MW = 34 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {7-27}
cysteine residue {C76}
MODIFICATION: cysteine residue {C225}
N-glycosylation site {N135}
cysteine residue {C225}
MODIFICATION: cysteine residue {C76}
Ser phosphorylation site {S298}
MISC-INFO: EC-2.4.99.-
Database Correlations
OMIM 606378
UniProt Q9H4F1
Pfam PF00777
Entrez Gene 27090
Kegg hsa:2709
ENZYME 2.4.99.7
References
- OMIM :accession 606378
- UniProt :accession Q9H4F1