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sialyltransferase 1; beta-galactoside alpha-2,6-sialyltransferase; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase; alpha 2,6-ST, B-cell antigen CD75 (SIAT1, ST6GAL1)
Function:
- transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates
- protein modification; protein glycosylation
- the soluble form derives from the membrane form by proteolytic processing
- the HB-6, CDW75, & CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme
CMP-N-acetylneuraminate +
beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine
CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-
1,4-N-acetyl-beta-D-glucosamine
Structure: belongs to the glycosyltransferase 29 family
Compartment:
- Golgi, Golgi stack membrane
- secreted
- membrane-bound form in trans cisternae of Golgi
- secreted into the body fluid
Related
CD75 antigen; lactosamine
General
glycoprotein
membrane protein
sialyltransferase
Properties
SIZE: MW = 47 kD
entity length = 406 aa
COMPARTMENT: golgi
MOTIF: transmembrane domain {10-26}
catalytic domain
SITE: 27-406
MOTIF: N-glycosylation site {N149}
N-glycosylation site {N161}
cysteine residue {C184}
MODIFICATION: cysteine residue {C335}
cysteine residue {C335}
MODIFICATION: cysteine residue {C184}
Database Correlations
OMIM 109675
UniProt P15907
Pfam PF00777
Entrez Gene 6480
KEGG correlations
ENZYME 2.4.99.1
References
- UniProt :accession P15907
- GGDB; Note: glycogene database
http://ggdb.muse.aist.go.jp/GGDB/index.jsp