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sialic acid synthase; N-acetylneuraminate synthase; N-acetylneuraminate-9-phosphate synthase; N-acetylneuraminic acid phosphate synthase; N-acetylneuraminic acid synthase (NANS, SAS)
Function:
1) produces N-acetylneuraminic acid (Neu5Ac) & 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN)
2) can use N-acetylmannosamine 6-phosphate & mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac & KDN
Phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O
phosphate + N-acetylneuraminate
Phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O
N-acylneuraminate 9-phosphate + phosphate
Structure: contains 1 AFP-like domain
Expression: ubiquitous
General
multifunctional enzyme
transferase
Properties
SIZE: entity length = 359 aa
MW = 40 kD
MOTIF: proline residue {2}
active site
AFP-like {294-353}
Database Correlations
OMIM 605202
UniProt Q9NR45
PFAM correlations
Entrez Gene 54187
Kegg hsa:54187
ENZYME correlations
References
UniProt :accession Q9NR45