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sialic acid-binding Ig-like lectin 15 (siglec-15, CD33 antigen-like 3, SIGLEC15, CD33L3)
Function:
- binds sialylated glycoproteins
- interacts with TYROBP & HCST
Structure:
- belongs to the immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: membrane
Expression:
- expressed in macrophage &/or dendritic cells of spleen & lymph nodes
General
glycoprotein
lectin
membrane protein
Properties
SIZE: MW = 36 kD
entity length = 328 aa
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-19}
immunoglobulin superfamily domain {40-158}
MOTIF: cysteine residue {C64}
MODIFICATION: cysteine residue {C142}
cysteine residue {C95}
MODIFICATION: cysteine residue {C104}
cysteine residue {C104}
MODIFICATION: cysteine residue {C95}
cysteine residue {C142}
MODIFICATION: cysteine residue {C64}
immunoglobulin superfamily domain {168-251}
MOTIF: N-glycosylation site {N172}
cysteine residue {C187}
MODIFICATION: cysteine residue {C237}
cysteine residue {C237}
MODIFICATION: cysteine residue {C187}
transmembrane domain {264-284}
Database Correlations
UniProt Q6ZMC9
Pfam PF07686
References
UniProt :accession Q6ZMC9