Shugoshin-like 2 (Tripin) (SGOL2)

Function: - role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex from centromeres after prophase (putative) - phosphorylated upon DNA damage, probably by ATM or ATR Structure: belongs to the shugoshin family Compartment: nucleus (putative), centromere - localizes to the centromere (putative) Alternative splicing: named isoforms=3

General

nuclear protein phosphoprotein

Properties

SIZE: MW = 145 kD entity length = 1265 aa COMPARTMENT: cell nucleus MOTIF: coiled coil {69-116} Ser phosphorylation site {S266} coiled coil {452-476} Ser phosphorylation site {S507} coiled coil {603-626} Thr phosphorylation site {T845}

References

UniProt :accession Q562F6